Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear. We screened 50,400 small molecules for their ability to promote axon outgrowth on inhibitory substrata. The most potent hits were the statins, which stimulated growth of all mouse- and human-patient-derived neurons tested, both in vitro and in vivo, as did combined inhibition of the protein prenylation enzymes farnesyltransferase (PFT) and geranylgeranyl transferase I (PGGT-1). Compensatory sprouting of motor axons may delay clinical onset of amyotrophic lateral sclerosis (ALS). Accordingly, elevated levels of PGGT1B, which would be predicted to reduce s...
Among the disciplines of medicine, the study of neurological disorders such as amyotrophic lateral s...
AbstractNeurons grow during development and extend long axons to make contact with their targets wit...
Extensive damage to a developed spinal cord can be devastating. The axons of nerve cells cannot rege...
SummarySuboptimal axonal regeneration contributes to the consequences of nervous system trauma and n...
Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodeg...
Trauma to the central nervous system (CNS) results in an irreversible disruption of axon tracts, oft...
A major reason why central nervous system (CNS) trauma and many neurodegenerative diseases demonstra...
Protein synthesis in dendrites has become an accepted cellular mechanism that contributes to activit...
Various molecular mechanisms including apoptosis, inflammation, oxidative stress, mitochondrial dysf...
Abstract: Axons are essential, vulnerable and often irreplaceable so it is essential to understand h...
Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury. Neu...
Amyotrophic Lateral Sclerosis is a devastating neurodegenerative disease that affects motor neurons....
Abstract Genetically engineered mouse model studies show that neuronal dysfunc-tion caused by protei...
Summary: Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult...
AbstractRobust axon regeneration occurs after peripheral nerve injury through coordinated activation...
Among the disciplines of medicine, the study of neurological disorders such as amyotrophic lateral s...
AbstractNeurons grow during development and extend long axons to make contact with their targets wit...
Extensive damage to a developed spinal cord can be devastating. The axons of nerve cells cannot rege...
SummarySuboptimal axonal regeneration contributes to the consequences of nervous system trauma and n...
Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodeg...
Trauma to the central nervous system (CNS) results in an irreversible disruption of axon tracts, oft...
A major reason why central nervous system (CNS) trauma and many neurodegenerative diseases demonstra...
Protein synthesis in dendrites has become an accepted cellular mechanism that contributes to activit...
Various molecular mechanisms including apoptosis, inflammation, oxidative stress, mitochondrial dysf...
Abstract: Axons are essential, vulnerable and often irreplaceable so it is essential to understand h...
Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury. Neu...
Amyotrophic Lateral Sclerosis is a devastating neurodegenerative disease that affects motor neurons....
Abstract Genetically engineered mouse model studies show that neuronal dysfunc-tion caused by protei...
Summary: Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult...
AbstractRobust axon regeneration occurs after peripheral nerve injury through coordinated activation...
Among the disciplines of medicine, the study of neurological disorders such as amyotrophic lateral s...
AbstractNeurons grow during development and extend long axons to make contact with their targets wit...
Extensive damage to a developed spinal cord can be devastating. The axons of nerve cells cannot rege...