Comparable fitness and transmissibility between Oseltamivir-Resistant Pandemic 2009 and seasonal H1N1 Influenza Viruses with the H275Y Neuraminidase Mutation

Conference Theme: Translating Health Research into Policy and Practice for Health of the PopulationPoster Presentations - Emerging / Infectious Diseases: no. P65-Ab0010INTRODUCTION: Neuraminidase (NA) inhibitors are one of the limited options for the control of influenza. The H275Y NA mutation, which confers resistance to oseltamivir carboxylate, was initially considered to be of little clinical consequence due to limited detection of this mutation in field isolates prior to 2007-2008, when a globally spreading H275Y variant emerged. Oseltamivir-resistant A(H1N1)pdm09 viruses with the H275Y NA mutation has been reported since 2009 but have not replaced the …published_or_final_versio