Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco, has been implicated as playing a role in carcinogenesis. Our previous study showed that passive cigarette smoking promoted inflammation-associated colonic adenoma formation in mice, and 5-lipoxygenase (5-LOX) plays an important role in this process. In the present study, we aimed to investigate whether nicotine could stimulate colon cancer cell proliferation and tumor growth in nude mice xenograft model and the possible mechanisms involved. Results showed that nicotine stimulated SW1116 colon cancer cell proliferation in a dose-dependent manner. Epidermal growth factor receptor (EGFR) and c-Src phosphorylation levels together with protein expression of 5-LOX were ...
Cigarette smoke is closely associated with high incidence rate of gastric cancer. Several evidences ...
[[abstract]]Nicotine in tobacco smoke is considered carcinogenic in several malignancies including l...
Cigarette smoke has always been the single most preventive cause of death in the world. In 2011, ove...
Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco, has been implicated as...
Cigarette smoking is a putative environmental risk factor for colon cancer. Nicotine, an active alka...
Early studies revealed that cigarette smoke promotes gastric cancer growth through the induction of ...
About 60 components in cigarette smoke are considered to be carcinogens, namely polycyclic aromatic ...
Nicotine is shown to be one of the carcinogenic agents for gastric cancer. Perturbation of epithelia...
Nicotine is the major addictive component of tobacco smoke. Although nicotine is generally thought t...
Cigarette smoking is implicated in the development of colon cancer. Furthermore, nicotine increases ...
Cigarette smoking is a recognized risk factor for colon cancer and nicotine, the principal active co...
Background: Colorectal cancer is one of the leading causes of cancer-related death throughout the wo...
Blockade of angiogenesis is a promising strategy to suppress tumor growth, invasion, and metastasis....
Cigarette smoking has been implicated in colon cancer. Nicotine is a major alkaloid in cigarette smo...
Nicotine, the major component in cigarette smoke, can promote tumor growth and angiogenesis, but the...
Cigarette smoke is closely associated with high incidence rate of gastric cancer. Several evidences ...
[[abstract]]Nicotine in tobacco smoke is considered carcinogenic in several malignancies including l...
Cigarette smoke has always been the single most preventive cause of death in the world. In 2011, ove...
Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco, has been implicated as...
Cigarette smoking is a putative environmental risk factor for colon cancer. Nicotine, an active alka...
Early studies revealed that cigarette smoke promotes gastric cancer growth through the induction of ...
About 60 components in cigarette smoke are considered to be carcinogens, namely polycyclic aromatic ...
Nicotine is shown to be one of the carcinogenic agents for gastric cancer. Perturbation of epithelia...
Nicotine is the major addictive component of tobacco smoke. Although nicotine is generally thought t...
Cigarette smoking is implicated in the development of colon cancer. Furthermore, nicotine increases ...
Cigarette smoking is a recognized risk factor for colon cancer and nicotine, the principal active co...
Background: Colorectal cancer is one of the leading causes of cancer-related death throughout the wo...
Blockade of angiogenesis is a promising strategy to suppress tumor growth, invasion, and metastasis....
Cigarette smoking has been implicated in colon cancer. Nicotine is a major alkaloid in cigarette smo...
Nicotine, the major component in cigarette smoke, can promote tumor growth and angiogenesis, but the...
Cigarette smoke is closely associated with high incidence rate of gastric cancer. Several evidences ...
[[abstract]]Nicotine in tobacco smoke is considered carcinogenic in several malignancies including l...
Cigarette smoke has always been the single most preventive cause of death in the world. In 2011, ove...