Organ inflammation and oxidative damages in fructose-fed adult offspring born of fructose-fed dams: modulation by maternal bitter melon supplementation

This journal suppl. is proceedings of EB 2014 MeetingSession: Nutrition - Animal Research Models of Fetal Programming: abstract no. 1033.6Open Access JournalHyperinsulinemia and dyslipidemia in offspring born of high fructose (F)-fed dams could be reversed by supplementing bitter melon juice extract to the F dams (FBM). However, when offspring were also fed F, only serum free fatty acid but not insulin level was normalized in those born of FBM dams. This study further examined the impacts of cross-generation F intake on organ inflammation in the offspring and the effects of maternal BM supplementation. Virgin female rats received control (C), F (60%), or BM-supplemented fructose (FBM; 1%) diet before conception until d 21 of lactation. Weaned offspring were fed to the C or F diet for 20 wk, forming C/C, C/F, F/F, FBM/F groups. Compared to ...link_to_OA_fulltex