Role of autophagy in chondrocyte differentiation

Poster presentation - Theme 3: Development & stem cellsMaintaining cell homeostasis during cellular differentiation is critical for the cell survival. Therefore, the balance between protein biogenesis and degradation is tightly regulated. The removal of the after-used and unwanted substances is not only important for protein turnover but also in regulating cellular differentiation and developmental process. The degradation of protein relies on two well-known systems, the Ubiquitin-proteasome system (UPS) and Autophagy-lysosomal system (ALS). Here, using the unique organization of the growth plate that depicts temporal and spatial “life time” of chondrocytes during ...postprin