Further evidence that the 3’Untranslated Region of the CHOP mRNA possesses mRNA destabilizing effect

Poster presentation - Theme 1: Cell biologyThe transcription regulatory factor known as Chop is commonly induced to express in stressed cells. In most cases, the expression of CHOP is associated with apoptosis. Although the regulation of CHOP expression at the transcriptional level has been studied to considerable details, the involvement of post-transcriptional mechanism such as mRNA stability has not been much addressed. We previously provided indirect evidence that the 3’UTR of CHOP mRNA had an mRNA destabilizing effect. The objective of this study was to provide more direct evidence to support this hypothesis. A reporter plasmid was constructed so as to express an EGFP mRNA that has its original ...postprin