Periodontitis, a common infectious disease, is initiated by various gram-negative bacteria and characterized by the destruction of the periodontal tissue. Here, we investigated the role of caspases, intracellular proteases that are the key mediators of apoptosis. We show that activation of caspase-3 and caspase-7 is considerably enhanced in gingival tissue from patients with periodontitis. We also demonstrate in in vitro experiments that various periodontopathic bacteria exert a direct growth-suppressing effect and, moreover, can trigger a host-mediated cytotoxic activity involving the CD95 death receptor. Our data suggest that caspase activation is a prominent feature in periodontitis-associated tissue injury. © 2005 Published by Elsevier ...
p. 1-6Background: Apoptosis is a highly controlled process of cell death that can be induced by peri...
Background: The mechanisms responsible for periodontal disease progression remain unclear. However, ...
Introduction: The caries and the periodontal disease (PD) are the most frequent alterations in the o...
AbstractPeriodontitis, a common infectious disease, is initiated by various gram-negative bacteria a...
This study investigated whether the prolonged survival of inflammatory cells in periodontal disease ...
Aggregatebacter actinomycetemcomitans serotype b in periodontal pockets indicates future periodontal...
Abstract Background Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in...
Introduction. Inflammatory mechanisms of chronic periodontitis (CP) may be linked to various forms o...
BackgroundLittle is known about the release of apoptotic proteins during periodontal breakdown. This...
Abstract Objective: Evidence of increased apoptosis is observed in periodontitis and may be associat...
Periodontal disease (Pd) is characterized by an increased osteoclast resorption and a decreased oste...
Background: Apoptosis is an evolutionary form of physiological cell death. Previous studies suggest ...
Porphyromonas gingivalis is an oral bacterium that causes pathology in a number of dental infections...
Periodontal disease (Pd) is characterized by an increased osteoclast resorption and a decreased oste...
Periodontitis is an inflammatory process that is associated with caspase activity. Caspases could th...
p. 1-6Background: Apoptosis is a highly controlled process of cell death that can be induced by peri...
Background: The mechanisms responsible for periodontal disease progression remain unclear. However, ...
Introduction: The caries and the periodontal disease (PD) are the most frequent alterations in the o...
AbstractPeriodontitis, a common infectious disease, is initiated by various gram-negative bacteria a...
This study investigated whether the prolonged survival of inflammatory cells in periodontal disease ...
Aggregatebacter actinomycetemcomitans serotype b in periodontal pockets indicates future periodontal...
Abstract Background Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in...
Introduction. Inflammatory mechanisms of chronic periodontitis (CP) may be linked to various forms o...
BackgroundLittle is known about the release of apoptotic proteins during periodontal breakdown. This...
Abstract Objective: Evidence of increased apoptosis is observed in periodontitis and may be associat...
Periodontal disease (Pd) is characterized by an increased osteoclast resorption and a decreased oste...
Background: Apoptosis is an evolutionary form of physiological cell death. Previous studies suggest ...
Porphyromonas gingivalis is an oral bacterium that causes pathology in a number of dental infections...
Periodontal disease (Pd) is characterized by an increased osteoclast resorption and a decreased oste...
Periodontitis is an inflammatory process that is associated with caspase activity. Caspases could th...
p. 1-6Background: Apoptosis is a highly controlled process of cell death that can be induced by peri...
Background: The mechanisms responsible for periodontal disease progression remain unclear. However, ...
Introduction: The caries and the periodontal disease (PD) are the most frequent alterations in the o...