Background. Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly affects adipose and muscle cells. The saturated free fatty acid palmitate is elevated in insulin-resistant states and may directly contribute to cellular insulin resistance. A spectrum of renal disease is associated with increased markers of insulin resistance, although direct causal mechanisms are not known. In the kidney, glomerular podocytes are novel insulin-sensitive cells that have the ability to rapidly transport glucose. In this study, we tested the hypothesis that palmitate would induce insulin resistance in podocytes.Methods. Conditionally immortalized human podocytes were cultured for up to 24 h with 375-750 μM palmitate. Functional effec...
Several lines of evidence suggest a pathogenic role of insulin resistance on kidney dysfunction. Pot...
Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indi...
The leading causes of albuminuria and end-stage renal failure are secondary to abnormalities in the ...
BACKGROUND: Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly affects...
<div><p>In the last few decades a change in lifestyle has led to an alarming increase in the prevale...
Microalbuminuria is significant both as the earliest stage of diabetic nephropathy and as an indepen...
La néphropathie diabétique (ND), principale cause d’insuffisance rénale chronique, est caractéri...
Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Los...
SummaryDiabetic nephropathy (DN) is the leading cause of renal failure in the world. It is character...
Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by...
Apoptosis of podocytes is considered critical in the pathogenesis of diabetic nephropathy (DN). Free...
Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Los...
AbstractPodocyte apoptosis is a potent mechanism of proteinuria in diabetic nephropathy. More detail...
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby caus...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Several lines of evidence suggest a pathogenic role of insulin resistance on kidney dysfunction. Pot...
Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indi...
The leading causes of albuminuria and end-stage renal failure are secondary to abnormalities in the ...
BACKGROUND: Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly affects...
<div><p>In the last few decades a change in lifestyle has led to an alarming increase in the prevale...
Microalbuminuria is significant both as the earliest stage of diabetic nephropathy and as an indepen...
La néphropathie diabétique (ND), principale cause d’insuffisance rénale chronique, est caractéri...
Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Los...
SummaryDiabetic nephropathy (DN) is the leading cause of renal failure in the world. It is character...
Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by...
Apoptosis of podocytes is considered critical in the pathogenesis of diabetic nephropathy (DN). Free...
Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Los...
AbstractPodocyte apoptosis is a potent mechanism of proteinuria in diabetic nephropathy. More detail...
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby caus...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Several lines of evidence suggest a pathogenic role of insulin resistance on kidney dysfunction. Pot...
Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indi...
The leading causes of albuminuria and end-stage renal failure are secondary to abnormalities in the ...