Measurement of oxygen concentration and distribution in the brain is essential for understanding the pathophysiology of stroke. Low-frequency electron paramagnetic resonance (EPR) spectroscopy with a paramagnetic probe is an attractive imaging modality that potentially can be used to map O2 concentration in the brain. We examined two nitroxides, 3-methoxycarbonyl-2,2, 5,5-tetramethyl-1-pyrrolidinyloxyl [2] and 3-acetoxymethoxycarbonyl-2,2,5,5- tetramethyl-1-pyrrolidinyloxyl [3], as pro-imaging agents to deliver 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl [1] across the blood-brain barrier (BBB). In primary cultured neurons, nitroxide [3] but not [2] was hydrolyzed by intracellular esterases to [1], which, being anionic at physiologic p...
Electron paramagnetic resonance (EPR) oximetry using particulate materials allows repeatable measure...
Oxidative stress, defined as a misbalance between the production of reactive oxygen species and the ...
Book chapter from "Nitroxides - Theory, Experiment and Applications", edited by Alexander I. Kokorin...
Scientific Session 6: Traumatic Brain InjuryMeasurement of oxygen concentration and distribution in ...
Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabo...
Reactive oxygen species (ROS) and compromised antioxidant defense may contribute to brain disorders ...
Nitroxides, unlike trityl radicals, have shorter T2 which until now were not detectable in vivo by a...
Molecular oxygen (O2) is essential to brain function and mechanisms necessary to regulate variations...
Relative perfusion, pO2, and bioreduction were measured simultaneously in vivo in tissues in mice by...
First published as an Advance Article on the web 25th September 2003 EPR spectroscopic techniques ha...
The present study is focused on the mechanism(s) of electron-paramagnetic resonance (EPR) signal red...
The detailed in vivo contrasting abilities of nitroxyl contrast agents in mouse brain were compared ...
Nitroxides are unusually stable free radicals and sensitive ''reporters'' of the chemico-physical en...
A novel method, called relaxo-oximetry, for rapid spatially resolved in vivo measurements of oxygen ...
AbstractThe development of an injectable probe formulation, consisting of perchlorotriphenylmethyl t...
Electron paramagnetic resonance (EPR) oximetry using particulate materials allows repeatable measure...
Oxidative stress, defined as a misbalance between the production of reactive oxygen species and the ...
Book chapter from "Nitroxides - Theory, Experiment and Applications", edited by Alexander I. Kokorin...
Scientific Session 6: Traumatic Brain InjuryMeasurement of oxygen concentration and distribution in ...
Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabo...
Reactive oxygen species (ROS) and compromised antioxidant defense may contribute to brain disorders ...
Nitroxides, unlike trityl radicals, have shorter T2 which until now were not detectable in vivo by a...
Molecular oxygen (O2) is essential to brain function and mechanisms necessary to regulate variations...
Relative perfusion, pO2, and bioreduction were measured simultaneously in vivo in tissues in mice by...
First published as an Advance Article on the web 25th September 2003 EPR spectroscopic techniques ha...
The present study is focused on the mechanism(s) of electron-paramagnetic resonance (EPR) signal red...
The detailed in vivo contrasting abilities of nitroxyl contrast agents in mouse brain were compared ...
Nitroxides are unusually stable free radicals and sensitive ''reporters'' of the chemico-physical en...
A novel method, called relaxo-oximetry, for rapid spatially resolved in vivo measurements of oxygen ...
AbstractThe development of an injectable probe formulation, consisting of perchlorotriphenylmethyl t...
Electron paramagnetic resonance (EPR) oximetry using particulate materials allows repeatable measure...
Oxidative stress, defined as a misbalance between the production of reactive oxygen species and the ...
Book chapter from "Nitroxides - Theory, Experiment and Applications", edited by Alexander I. Kokorin...