The purpose of the present investigations was to determine whether or not SIN-1, a metabolite of molsidomine that spontaneously releases nitric oxide, stimulates the production of adenosine-3',5'-cyclic monophosphate (cyclic AMP) and of guanosine-3',5'-cyclic monophosphate (cyclic GMP) in endothelial cells. All experiments were performed on first or second passage cultured porcine aortic endothelial cells. SIN-1 induced a time- and concentration-dependent accumulation of cyclic GMP but not of cyclic AMP. The production of cyclic GMP evoked by SIN-1 but not evoked by human α-natriuretic polypeptide was inhibited by treatment of the cells with either methylene blue (an inhibitor of soluble guanylate cyclase) and hemoglobin (a scavenger of nit...
The cytokine interleukin 1 (IL-1) inhibits contractile responses in rat aorta by causing endothelium...
In canine systemic veins, in contrast to what is observed in mammalian systemic arteries, endotheliu...
Soluble guanylyl cyclase (sGC) is the principal enzyme in mediating the biological actions of nitric...
1. The effects of bradykinin, adenosine diphosphate, calcium ionophore A23187 and nitric oxide on th...
AbstractThe role of nitric oxide (NO) and guanosine 3′,5′-cyclic monophosphate (cyclic GMP) in cellu...
The response to small peptides such as Arg-vasopressin, oxytocin and tachykinins was investigated in...
Summary 1 In vascular smooth muscle cells, relaxant actions of guanosine--3′,5′-cyclic monophosphat...
Oxytocmn, bradykinin, melittin and A231 87 increased cyclic GMP levels through activation of soluble...
The response to small peptides such as Arg-vasopressin, oxy-tocin and tachykinins was investigated i...
AbstractIn this study, the role of cyclic GMP, the end product of the NO-cyclic GMP signalling pathw...
Human peripheral blood mononuclear cells were stimulated in vitro with the bacterial endotoxin lipop...
The effects of 3-morpholinosydnonimine (SIN-1) were studied in isolated canine basilar arteries. Rin...
lin increases NO-stimulated guanylate cyclase activity in cultured VSMC cells while raising the redo...
International audienceThe effects of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) on...
The nitric oxide (NO)-generating drug sodium nitroprusside (SNP) has been assayed on DNA synthesis i...
The cytokine interleukin 1 (IL-1) inhibits contractile responses in rat aorta by causing endothelium...
In canine systemic veins, in contrast to what is observed in mammalian systemic arteries, endotheliu...
Soluble guanylyl cyclase (sGC) is the principal enzyme in mediating the biological actions of nitric...
1. The effects of bradykinin, adenosine diphosphate, calcium ionophore A23187 and nitric oxide on th...
AbstractThe role of nitric oxide (NO) and guanosine 3′,5′-cyclic monophosphate (cyclic GMP) in cellu...
The response to small peptides such as Arg-vasopressin, oxytocin and tachykinins was investigated in...
Summary 1 In vascular smooth muscle cells, relaxant actions of guanosine--3′,5′-cyclic monophosphat...
Oxytocmn, bradykinin, melittin and A231 87 increased cyclic GMP levels through activation of soluble...
The response to small peptides such as Arg-vasopressin, oxy-tocin and tachykinins was investigated i...
AbstractIn this study, the role of cyclic GMP, the end product of the NO-cyclic GMP signalling pathw...
Human peripheral blood mononuclear cells were stimulated in vitro with the bacterial endotoxin lipop...
The effects of 3-morpholinosydnonimine (SIN-1) were studied in isolated canine basilar arteries. Rin...
lin increases NO-stimulated guanylate cyclase activity in cultured VSMC cells while raising the redo...
International audienceThe effects of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) on...
The nitric oxide (NO)-generating drug sodium nitroprusside (SNP) has been assayed on DNA synthesis i...
The cytokine interleukin 1 (IL-1) inhibits contractile responses in rat aorta by causing endothelium...
In canine systemic veins, in contrast to what is observed in mammalian systemic arteries, endotheliu...
Soluble guanylyl cyclase (sGC) is the principal enzyme in mediating the biological actions of nitric...