Bone regeneration with resorbable polylactide membrane and sponge in sn unstable fracture model in rabbit radius

Bone regeneration with resorbable polylactide membrane and polylactide sponge in a 20 mm bone defect in rabbit radii was investigated. The biomechanical strength of the bone fixation construct with reinforcement by membrane and sponge was determined. It was found that membrane serves as a barrier to prevent fibrous tissue to grow into the bone defect and preserves the osteogenic factors and cells. Results show that the size, 20 mm, well exceeded the critical size defect of rabbit so resorbable polylactide sponge can be used to regenerate long segmental defect.link_to_subscribed_fulltex