Lowering the doses of mifepristone and gemeprost for early abortion: A randomised controlled trial
- Prasad, RNV
- Templeton, A
- Dhall, GI
- Calder, A
- GomezAlzugaray, M
- Ho, PC
- PretnarDarovec, A
- Sikazwe, C
- JunKang, C
- Bygdeman, M
- Kóvacs, L
- Kavkasidze, G
- LiJuan, S
- Noonan, E
- Ali, M
- Peregoudov, A
- Laperrière, N
- Von Hertzen, H
- Grimes, D
- Ali, M
DOIAbstract
Objective: To test the efficacy of lower doses of mifepristone and gemeprost for medical induction of early abortion. Design: Randomised controlled trial. Participants were blinded as to the therapy and physicians to the dose of mifepristone. Setting: Thirteen hospital gynaecological units in different continents. Participants: 1224 healthy pregnant women requesting medical abortion at <57 days from last menses. Intervention: Random allocation to one of four regimens: mifepristone 50 mg by mouth followed by either 0.5 mg or 1.0 mg gemeprost vaginally on day 3; mifepristone 200 mg by mouth followed by either 0.5 mg or 1.0 mg gemeprost vaginally. We concealed the allocation sequence from clinicians enrolling participants, and maintained doubl...
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