The effects of endogenous and of exogenous norepinephrine were studied in isolated rings of canine left circumflex coronary artery and its first ventricular branch. Norepinephrine was released from adrenergic nerve endings by transmural electrical stimulation and by tyramine. In rings contracted with prostaglandin F(2α) transmural electrical stimulation resulted in frequency dependent relaxations which were blocked by propranolol or tetrodotoxin; tyramine and exogenous norepinephrine caused concentration-dependent relaxations which were blocked by propranolol. The tyramine-induced relaxations also were inhibited by cocaine. The left circumflex artery was less sensitive than its branch to β-adrenergic activation; this difference was signific...
Experiments were designed to characterize alpha-1 and alpha-2 adrenoceptor-mediated effects in the c...
The purpose of this study was to characterize the adrenergic and cholinergic responsiveness of isola...
The purpose of the present study was to determine whether sympathetic coronary vasoconstrictor respo...
The effects of inhibition of endogenous prostaglandin synthesis on the release of norepinephrine fro...
neuroeffector junction in canine coronary arteries. Prejunctional and postjunctional actions of endo...
Ouabain, when applied to rings of the left circumflex coronary artery of the dog (which contains bot...
Endothelin-1 contracts vascular smooth muscle and inhibits release of neurotransmitter from adrenerg...
Experiments were performed to determine the conditions in which norepinephrine release from adrenerg...
The effects of norepinephrine (0.1 and 1.0 Mg/kg, iv) on coronary blood flow and resistance, left ve...
Both a- (vasoconstrictor) and (3- (vasodilator) receptor activity was demon-strated in the coronary ...
The relationship between adrenergic nerve activity and neuronal uptake was investigated. Helically c...
Experiments were designed to define the postjunctional alpha adrenoceptor subtype(s) in large canine...
SUMMARY We performed experiments to determine whether or not acetylcholine exerts a prejunc-tional i...
Experiments were designed to investigate the importance of the endothelium in relaxation of isolated...
The perfused isolated rabbit ear artery was used as a vascular model to compare the constrictor resp...
Experiments were designed to characterize alpha-1 and alpha-2 adrenoceptor-mediated effects in the c...
The purpose of this study was to characterize the adrenergic and cholinergic responsiveness of isola...
The purpose of the present study was to determine whether sympathetic coronary vasoconstrictor respo...
The effects of inhibition of endogenous prostaglandin synthesis on the release of norepinephrine fro...
neuroeffector junction in canine coronary arteries. Prejunctional and postjunctional actions of endo...
Ouabain, when applied to rings of the left circumflex coronary artery of the dog (which contains bot...
Endothelin-1 contracts vascular smooth muscle and inhibits release of neurotransmitter from adrenerg...
Experiments were performed to determine the conditions in which norepinephrine release from adrenerg...
The effects of norepinephrine (0.1 and 1.0 Mg/kg, iv) on coronary blood flow and resistance, left ve...
Both a- (vasoconstrictor) and (3- (vasodilator) receptor activity was demon-strated in the coronary ...
The relationship between adrenergic nerve activity and neuronal uptake was investigated. Helically c...
Experiments were designed to define the postjunctional alpha adrenoceptor subtype(s) in large canine...
SUMMARY We performed experiments to determine whether or not acetylcholine exerts a prejunc-tional i...
Experiments were designed to investigate the importance of the endothelium in relaxation of isolated...
The perfused isolated rabbit ear artery was used as a vascular model to compare the constrictor resp...
Experiments were designed to characterize alpha-1 and alpha-2 adrenoceptor-mediated effects in the c...
The purpose of this study was to characterize the adrenergic and cholinergic responsiveness of isola...
The purpose of the present study was to determine whether sympathetic coronary vasoconstrictor respo...