Novel luminescent cyclometalated and terpyridine gold(III) complexes and DNA binding studies

Two gold complexes, [Au(III){4-MeOPh-(Phbipy)}Cl]·CF3SO3 1 and [Au(III)(4-MeOPh-terpy)Cl]·(ClO4)2 2 [4-MeOPh-(Phbipy) = 4'-(4-methoxyphenyl)-6'-phenyl-2,2'-bipyridine, 4-MeOPh-terpy = 4'-(4-methoxyphenyl)-2,2',6',2'-terpyridine] are prepared, and their interactions with calf-thymus DNA, poly(dG-dC)2 and poly(dA-dT)2, investigated by spectroscopic means; in the reaction with ct DNA, 1 has a higher binding constant than 2, but the latter has a higher degree of AT specificity.link_to_subscribed_fulltex