Effect of diffusion time on liver DWI

Oral Presentation - Session 26: Body Diffusion: no. 0263Conference Theme: Adapting MR in a Changing WorldIn liver, diffusion decay can depend on not only b-value but also the diffusion time (∆) because water molecule diffusion is hindered and restricted by cellular microstructures, such as cell membrane, cytoskeleton, and macromolecules in tissue environment. In this study, we aimed to investigate the dependence of various diffusion measurements on diffusion time ∆ by acquiring and analyzing DW signal with various b-values at different diffusion times (∆s) in normal rat liver in vivo. Restricted diffusion behavior was observed in liver in vivo, demonstrating the effect of both b-value and ∆ on liver DWI quantification.link_to_OA_fulltextThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 26