The determination of antithrombin III by radioimmunoassay and its clinical application
- Chan, V
- Chan, TK
- Wong, V
DOIAbstract
A radioimmunoassay (RIA) had been developed for the determination of antithrombin III (AT III) in man. The detection limit was 25 μg/dl. AT III-RIA level and biological activity (anti-Xa) were significantly correlated (r=0.737, P<0.001). Plasma levels in 36 healthy males (mean ± SD, and in mg/dl) and 21 healthy females (19.1±2.4 mg/dl) were similar. Serial AT III measurements in normal menstruating females showed lower levels during midcycle and higher concentrations during menstruation. In carcinomas, the AT III levels were lower than normal, particularly in hepatocellular carcinoma. In cirrhosis of liver, the levels were markedly decreased in some patients were below that found in congenital AT III deficiency. Patients with deep vein thro...
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