rhLBP and P. gingivalis LPS crosstalk in modulating cytokine expression

Periodontal Research - Pathogenesis 17 - Keynote Address and Host-Bacterial Interactions (Oral Session): no. 67OBJECTIVES: LPS-binding protein (LBP) plays an important role in LPS-CD14 interaction to modulate innate host response. Our recent studies find that LBP expression profile is associated with periodontal conditions and its expression is modulated differentially by P. gingivalis LPS with lipid A structure heterogeneity. This study further investigated the effects of LBP and its crosstalk with P. gingivalis LPS1690 or LPS1435/1449 on the expression of IL-6 and IL-8 in human oral kerati...link_to_OA_fulltex