The Effect Of Holy Basil (Ocimum Sanctum) Leaf Extract On Sgot And Sgpt Levels In Mice (Mus Musculus) Exposed By Lead Acetate

The aim of this study was to know the effect of holy basil (Ocimum sanctum) leaf extract on SGOT and SGPT levels in mice (Mus musculus) exposed by lead acetate. The research used 20 adult male mice as experimental animals which divided into five groups; C(-) as negative control which were given Tween 80 1% and aquadest, C(+) was given Tween 80 1% and lead acetate 20 mg/kgBW, T1 was given Ocimum sanctum leaf extract 140 mg/kgBW and lead acetate 20 mg/kgBW, T2 was given Ocimum sanctum leaf extract 280 mg/kgBW and lead acetate 20 mg/kgBW, T3 was given Ocimum sanctum leaf extract 560 mg/kgBW and lead acetate 20 mg/kgBW. Samples were taken on day 25th. Then the data were compared using ANOVA and DMRT test. In SGOT, C(-) and T2 was significantly different with C(+). Meanwhile in SGPT, C(-) was not significantly different with T2, but T2 was also not significantly different with C(+), T1, and T3. C(-) was significant different with C(+). T2 was the group with the highest decrease in SGOT and SGPT level among the treatment group because the antioxidant content can effectively prevent oxidative stress caused by lead acetate. It can be concluded that the Ocimum sanctum leaf extract has an effect to decrease the SGOT level of mice exposed by lead acetate effectively at a dose of 280 mg/kgBW level, but it does not have an effect to decrease the SGPT level of mice exposed by lead acetate