Haemoglobin Q-Thailand and hereditary spherocytosis in a chinese family

Leung, KFS
Au, WY
Chan, AYY
Chan, LC
Waye, JS
Chui, DHK
Ma, SK

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Publication date

January 2001

DOI

10.1046/j.1365-2257.2001.00349.x

Publisher

Wiley

ISSN

0141-9854

Journal

Clinical & Laboratory Haematology

Citation count (estimate)

Abstract

A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining α1 globin gene on a chromosome 16 containing the (-α 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.link_to_subscribed_fulltex