Disease gene mapping is the first step towards our ultimate goal for understanding the etiology of a disease. Family-based linkage analysis and population-based association studies have been combining successfully as the workhorses for hunting disease genes in the past decades and are performed concurrently. To attain an adequate balance between maximizing the chance of discovering potential disease-causing genes and minimizing the cost of study implementation, an optimal study design is necessary. Important issues on the basics of human genetics, principles of linkage analysis and association studies, advantages and limitations of individual strategies, as well as practical procedures in conducting disease gene mapping are discussed in det...
Both linkage and association methods have been used to localise and identify genes related to behavi...
Genetic linkage analysis can be used to identify regions of the genome that contain genes that predi...
Mapping genes for complex human traits is facilitated by two commonly used analytical methods: linka...
Genetic mapping by linkage analysis has been an invaluable tool in the positional strategy to identi...
Association mapping seeks to identify marker alleles present at significantly different frequencies ...
For complex diseases, we often sample and genotype affected sibships to map the disease of interest ...
The spread and clinical manifestations of an infection in human populations depend on a variety of f...
Because the genotype-phenotype correlation information is investigated differently by linkage and as...
Complex diseases like type 2 diabetes, heart disease and cancer have a tremendous impact on the worl...
Association mapping in linked regions is a current major approach for the identification of genes fo...
Association mapping has successfully identified common SNPs associated with many diseases. However, ...
For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and ...
In the 20th century geneticists began to unravel some of the simpler aspects of the etiology of inhe...
This chapter describes the main issues that genetic epidemiologists usually consider in the design o...
In this paper, a genome search is performed on the GAW Problem 1 data, in an attempt to determine wh...
Both linkage and association methods have been used to localise and identify genes related to behavi...
Genetic linkage analysis can be used to identify regions of the genome that contain genes that predi...
Mapping genes for complex human traits is facilitated by two commonly used analytical methods: linka...
Genetic mapping by linkage analysis has been an invaluable tool in the positional strategy to identi...
Association mapping seeks to identify marker alleles present at significantly different frequencies ...
For complex diseases, we often sample and genotype affected sibships to map the disease of interest ...
The spread and clinical manifestations of an infection in human populations depend on a variety of f...
Because the genotype-phenotype correlation information is investigated differently by linkage and as...
Complex diseases like type 2 diabetes, heart disease and cancer have a tremendous impact on the worl...
Association mapping in linked regions is a current major approach for the identification of genes fo...
Association mapping has successfully identified common SNPs associated with many diseases. However, ...
For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and ...
In the 20th century geneticists began to unravel some of the simpler aspects of the etiology of inhe...
This chapter describes the main issues that genetic epidemiologists usually consider in the design o...
In this paper, a genome search is performed on the GAW Problem 1 data, in an attempt to determine wh...
Both linkage and association methods have been used to localise and identify genes related to behavi...
Genetic linkage analysis can be used to identify regions of the genome that contain genes that predi...
Mapping genes for complex human traits is facilitated by two commonly used analytical methods: linka...