PENGARUH KONSENTRASI CROSSLINKER CaCl2 TERHADAP KARAKTERISTIK MIKROSFER CIPROFLOXACIN HCl-ALGINAT

The aim of this research was to determine the effect of CaCl2 crosslinker concentrations on the characteristics including particle morphology (shape and surface), particle size, swelling index, drug loading, entrapment efficiency, yield of Ciprofloxacin HCl-Alginate. Microspheres were prepared by ionothropic gelation by method with aerosolization technique. Microspheres preparation involved sodium alginat as polymer and CaCl2 as crosslinker, Ciprofloxacin HCl-Alginate micropheres were dried using freeze dryer with maltodextrin as lyoprotectant. The concentrations of sodium alginate were used 2%, and concentrations of CaCl2 2%,3% and 4% were used. The microspheres were evaluated included DTA, FT-IR, SEM, particle size distribution using optical microscopy, drug loading (DL), entrapment efficiency (EE), and yield. The microspheres size showed the diameter size of particle were below 5 μm. The results of DL formula F1, F2 and F3 were 7,25±0,24%; 6.26±0,79% and 7,20±0,65%, analysis statistics showed sig value>0,05, the effect of CaCl2 concentrations were not significant for DL. Results EE of formula F1, F2, and F3 were 68,11±1,41%; 61,71±7,71% ; 64,67±3,82%, analysis statistics showed sig value>0,05 means the effect of CaCl2 were not significant for EE. Yield formula F1,F2 and F3 were 73.91±3.17 %; 71.75±3.46%;71.81±6.21%, analysis statistics showed sig value>0,05 means the effect of CaCl2 were not significant for yield. And swelling index based on mass and particle size of Ciprofloxacin HCl-alginat microspheres of all formulas showed index value less than 10