PROFIL EKSPRESI p16INK4a DAN TIPE HUMAN PAPILLOMA VIRUS (HPV) PADA PASIEN KONDILOMA AKUMINATA WANITA di RSUD Dr SOETOMO SURABAYA

Background: Condyloma acuminata is a sexually transmitted disease caused by Human Papilloma Virus (HPV). High-risk HPV has the ability to develop into malignancy, whereas low-risk HPV is very rarely cause malignancy. The p16ink4a examination is used to detect potentially malignant HPV. Detection of HPV genotype by using PCR has a very high sensitivity. Purpose: This study is to determine the expression of p16INK4a in condyloma acuminata lesions with low risk HPV infection, high risk HPV infection, and multiple HPV infection infections Methods: This is cross sectional study conducted at Sexual Transmitted Infection Division of Outpatient Clinic, Dr. Soetomo General Hospital Surabaya. 13 patients with condyloma acuminata were examined genotyping by PCR and p16INK4a by immunohistochemistry. Sample was taken from the lession of condyloma acuminta by biopsy. Results: There were 5 patients with diffuse p16ink4a. The results of diffuse p16ink4a indicate that in these patients have the ability to develop into malignancy. Conclusions: Further study (cohort prospective) in condyloma acuminata patients with diffuse p16 features to determine the probability of malignancy in patient