PENGARUH PEMBERIAN EKSTRAK KEMANGI (Ocimum sanctum L.) TERHADAP DERAJAT KERUSAKAN MUKOSA GASTER MENCIT (Mus musculus) YANG DIINDUKSI ASPIRIN

Introduction: Long-term uses in high-dose therapy of aspirin causes gastric mucosal damage. Herbs which known has flavonoid compounds as gastroprotective is Ocimum sanctum L.. Objectives: This study aimed to determine the effect of extracts of Ocimum sanctum L. on the degree of mice (Mus musculus) gastric mucosal damage induced by aspirin. Material and methods: This experimental research used post-test only control group design. Thirty male mice average weight 20-30 grams were divided into 5 groups. Four groups (KP, P1, P2 and P3) were induced by aspirin 56 mg/kgBW for 7 days. One group (N) was administered with CMC Na 0,5% for 14 days. Group P1, P2, and P3 was administered with extract of Ocimum sanctum L. dosage 28, 42, and 56 mg/kgBW on day 8-14. All treatments were given per oral, once a day. The whole group was terminated on day 15, except KP which terminated on the 8th day. Gastric fundus was taken for Hematoxylin eosin staining (HE) and observed under a microscope, magnification of 400x in 5 visual fields to assess the degree of gastric mucosal damage by Esplugues & Whittle scoring system. Statistical analysis was done with Kruskal-Wallis and Mann-Whitney test. P value of