POTENSI PERLINDUNGAN PASTA TOMAT (Lycopersicon esculantum) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL MENCIT (Mus musculus) YANG DIPAPAR BORAKS

This research was aimed to evaluate the potential protection of tomato paste (Lycopersicon esculatum) against kidney histopathologic picture of mice (Mus musculus) exposed to borax. Twenty-four male mice (Mus musculus) 60-90 days old with average weight of 20 g is used. These animals were divided into six groups (P0, P1, P2, P3, P4, and P5). P0 treated with sterile aquadest of 0.1 ml / 20g Bw / day, P1 is treated with borax 7.5 mg / 20g Bw / day, P2 is treated with tomato paste 0,3 g / 20g Bw / day, P3 is treated with tomato paste 0 , 15 g / 20g Bw / day and borax 7.5 mg / 20g Bw / day, P4 is treated with tomato paste 0,3 g / 20g Bw / day and borax 7.5 mg / 20g Bw / day, and P5 treated with tomato paste 0.45 g / 20g Bw / day and borax 7.5 mg / 20g Bw / day. This research has been conducted for 14 days. Data were compared using non-parametric test of Kruskal-Wallis and showed that among the treatment group contained significant effect (p <0.05), then continued with Man- Whitney test using SPSS 20.0 for windows. The results showed that the tomato paste 0.45 g / BB 20g daily can reduce the degree of kidney damage in mice exposed to borax significantly (p