Uji aktivitas analgesik senyawa baru turunan parasetamol pada mencit (mus musculus) dengan metode hot plate

Paracetamol is analgesic drug that is widely used in Indonesia. A modification of paracetamol structure had been conducted which produced two compounds of paracetamol derivatives, that are 4’-acetamidophenyl-2-chlorobenzoat and 4’-acetamidophenyl-3-chlorobenzoat. These compounds are expected to carry bigger activity compared to paracetamol since they have higher lipofility. The purpose of this research was to determine an analgesic activity of new parasetamol derivatives. The analgesic activity test was administered using hot plate method in 550C ± 0,50C using mouse as an animal test. Analgesic activity was determined by noting down predrug latency and postdrug latency at the 30th, 60th, 90th, and 120th minutes after the assignment of control supply of CMC-Na 0,5%, paracetamol as a comparison (100 mg/kg BB) and compound test 1 and 2 (100 mg/kg BB) to each mouse group. The result of Maximum Possible Effect produced compound 1 MPE of 29,7% and compound 2 MPE of 37,04%. Based on the statistical analysis of ANOVA test, it can be concluded that the difference of activities is meaningful in the 60th minute after drug supply. An analysis on stability, toxicity, physical, chemical and pharmacological nature of the new compounds derivative of paracetamol is also recommended