Lactic-acid-induced ATP release from rat skeletal muscular L6 cells is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) channels

Poster SessionThis journal issue is proceedings of ICSM 2008BACKGROUND AND OBJECTIVE: We had previously shown that lactic-acidinfusion increased the interstitial ATP concentration of perfused rat skeletal muscle in-vivo, which could be inhibited by CFTRinh-172, a specific inhibitor of CFTR. A stable rat skeletal muscular L6 cell line was used in this study to confirm that skeletal muscle cells (rather than nerve or vascular cells) were responsible for the acidosis-induced ATP release; the role of CFTR in mediating the ATP efflux during lactic acid incubation was confirmed using …link_to_OA_fulltextThe 12th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Faculty of Medicine, the University of Hong Kong, Hong Kong, China, 13-14 December 2008. In Journal of the Hong Kong College of Cardiology, 2008, v. 16 n. 2, p. 65, abstract no. P