Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma

Dickkopf-1 (DKK1), an antagonist of the Wnt/β-catenin pathway, has recently been found upregulated in some cancers. To investigate the role of DKK1 in human hepatocellular carcinoma (HCC), the transcript levels in two independent cohorts of approximately 200 and 100 pairs of human HCC and the corresponding non-tumorous liver tissue were evaluated with GeneChip microarray and real-time …link_to_OA_fulltextThe 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010), Vienna, Austria, 14-18 April 2010. In Hepatology, 2010, v. 52 suppl. S1, p. 1134A, abstract no. 170