Rate-dependent block of hkv1.5 channels and the molecular determinant by the natural flavone acacetin

This journal issue is proceedings of ICSM 2010Abstracts for Oral CommunicationsWe have recently demonstrated that the natural flavone acacetin is an atrialselective compound that inhibits ultra-rapid delayed rectifier potassium current (IKur) and transient outward potassium current (Ito) in human atrial myocytes, and also acetylcholine-activated potassium current (IK.ACh). It increased atrial effective refractory period and effectively prevented atrial fibrillation (AF) in anesthetized dogs without prolonging QT interval of ECG. The present study was designed to ...link_to_OA_fulltextThe 14th Annual Scientific Meetingof the Institute of Cardiovascular Science and Medicine, Hong Kong, China, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 78, abstract no. P2