Rationale: l-Stepholidine (l-SPD), a tetrahydroprotoberberine alkaloid, possesses a pharmacological profile of a D 1/5-HT 1A agonist and a D 2 antagonist. This unique pharmacological profile makes it a promising novel antipsychotic candidate. Preliminary clinical trials and animal experiments suggest that l-SPD improves both positive and negative symptoms of schizophrenia without producing significant extrapyramidal side effects. To further explore the antipsychotic mechanisms of the drug, we studied the effects of l-SPD on the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) using in vivo single-unit recording technique in rats. Result: We found that l-SPD increased VTA DA neurons firing rate and induced slow oscillati...
The project concentrated on characterising the effect of D4 receptor activation in the context of an...
A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to ac...
1. The aim of the present study was to evaluate the contribution of serotonin (5-HT) and dopamine (D...
Stepholidine (SPD), a natural product isolated from the Chinese herb Stephania, possesses dopamine (...
Psychostimulant reinforcement is mediated by stimulation of both dopamine (DA) D1-like and D2-like r...
The role of the 5-HT(2A) receptor in modulating amphetamine-induced inhibition of dopamine neuronal ...
(-)-Stepholidine (SPD) is an antagonist of normosensitive dopamine (DA) receptors, but it exhibits D...
Ten years ago, the rediscovery of the atypical antipsychotic drug clozapine represented a breakthrou...
Abstract: (-)-Stepholidine (SPD), a natural product isolated from the Chinese herb Stephania, posses...
Combination of dopamine D3 antagonism, serotonin 5-HT1A partial agonism, and antagonism at 5-HT2A le...
Schizophrenia is a severe mental disorder featuring psychotic, depressive, and cognitive alterations...
Combination of dopamine D3 antagonism, serotonin 5-HT1A partial agonism, and antagonism at 5-HT2A le...
The serotonin 2B receptor (5-HT2BR) is the most recent addition to the 5-HT2R family. During the las...
Dopamine is fundamental in human behavior for movement, cognition and reward. A dysfunctional dopami...
Rationale: Activation of metabotropic glutamate (mGlu) 2/3 receptors may provide a novel strategy fo...
The project concentrated on characterising the effect of D4 receptor activation in the context of an...
A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to ac...
1. The aim of the present study was to evaluate the contribution of serotonin (5-HT) and dopamine (D...
Stepholidine (SPD), a natural product isolated from the Chinese herb Stephania, possesses dopamine (...
Psychostimulant reinforcement is mediated by stimulation of both dopamine (DA) D1-like and D2-like r...
The role of the 5-HT(2A) receptor in modulating amphetamine-induced inhibition of dopamine neuronal ...
(-)-Stepholidine (SPD) is an antagonist of normosensitive dopamine (DA) receptors, but it exhibits D...
Ten years ago, the rediscovery of the atypical antipsychotic drug clozapine represented a breakthrou...
Abstract: (-)-Stepholidine (SPD), a natural product isolated from the Chinese herb Stephania, posses...
Combination of dopamine D3 antagonism, serotonin 5-HT1A partial agonism, and antagonism at 5-HT2A le...
Schizophrenia is a severe mental disorder featuring psychotic, depressive, and cognitive alterations...
Combination of dopamine D3 antagonism, serotonin 5-HT1A partial agonism, and antagonism at 5-HT2A le...
The serotonin 2B receptor (5-HT2BR) is the most recent addition to the 5-HT2R family. During the las...
Dopamine is fundamental in human behavior for movement, cognition and reward. A dysfunctional dopami...
Rationale: Activation of metabotropic glutamate (mGlu) 2/3 receptors may provide a novel strategy fo...
The project concentrated on characterising the effect of D4 receptor activation in the context of an...
A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to ac...
1. The aim of the present study was to evaluate the contribution of serotonin (5-HT) and dopamine (D...