Human cytomegalovirus inhibited megakaryocytic differentiation, maturation and induced apoptosis in vitro

Poster Session: Disorders of Platelet Number or Function Poster II: abstract no. 2413Human cytomegalovirus (HCMV) can cause life-threatening infection in immunocomprimised individuals, such as patients undergoing intensive chemotherapy or bone marrow transplantation. Thrombocytopenia is one of the manifestations in active HCMV infection, which may be a consequence of viral suppression on megakaryopoiesis. The exact underline mechanisms remain uncertain. Our previous studies suggested that HCMV directly infects megakaryocytic progenitors and inhibits their proliferation. Colony-formation of HCMV-infected CFU-MK decreased in ...link_to_OA_fulltextThe 51st ASH Annual Meeting And Exposition, New Orleans, LA., 5-8 December 2009