Invasive Penicillium marneffel infection in children without Acquired Immunodeficiency Syndrome (AIDS) - an indicator disease for primary Immunodeficiency

Poster presentation I: P1-044OBJECTIVES: Penicillium marneffei infection is indigenous to Southeast Asia. Most cases occurred in individuals with AIDS or secondary immunodeficiency. P. marneffei infection in HIV-negative, otherwise healthy persons is rarely reported. From 1996 – 2009, we diagnosed P. marneffei infection in 6 children. Our aim is to review their clinical and immunological features, and to conduct a systematic literature review on P. marneffei infection in children. METHODS: Case records of our patients with P. marneffei infection were reviewed. A systematic review of the English and Chinese literature (1980 to 2009) from Pubmed, China Journal Net and Taiwan Electronic Periodical Services, using the keyword ‘Penicillium marneffei’ or its Chinese equivalent was performed. Case reports/series on patients