ADAMTS9 inhibits angiogenesis and induces apoptosis in nasopharyngeal carcinoma

Poster Session 5 - Novel Tumor Suppressor Genes 1: abstract no. 3058BACKGROUND AND AIMS: A disintegrin-like and metalloprotease with thrombospondin type 1 motif 9 (ADAMTS9), a gene mapping to 3p14.2, has been shown to be silenced by promoter hypermethylation in nasopharyngeal carcinoma (NPC). The ADAMTS family consists of 19 secretion protein members consisting of a disintegrin domain, metalloproteinase domain, and different numbers of thrombospondin type 1 motifs. ADAMTS9 encodes a member of a large family of 19 metalloproteases involved in maturation of precursor proteins, extracellular matrix remodeling, cell migration, and inhibition of angiogenesis. Although the related ...link_to_OA_fulltextThe 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010