Granulin-epithelin precursor (GEP) is an oncofetal protein involved in fetal liver development and liver cancer

Poster Presentations - Cancer Stem Cell Biology 2: abstract 4246This journal suppl. entitled: Proceedings: AACR 101st Annual Meeting 2010...BACKGROUND AND OBJECTIVES: Granulin-epithelin precursor (GEP) is a novel pluripotent growth factor regulating embryo development, wound repair and tumorigenesis. Our group previously has showed that GEP was over-expressed in over 70% of liver cancer. Besides, functional studies demonstrated that GEP controlled liver cancer proliferation, invasion and tumorigenicity. In this study, we aim to examine the time-frame of GEP expression during fetal liver development, and to characterize the properties of ...link_to_OA_fulltex