Granulin-epithelin precursor modulates chemo-resistance in liver cancer

This journal suppl. entitled: Proceedings: AACR 101st Annual Meeting 2010...Poster Presentations - Mechanisms of Resistance 3: Chemotherapeutics: abstract 2556BACKGROUND AND OBJECTIVE: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and is responsible for 80% of the primary liver tumors in adults. HCC is found to be resistant to most current chemo-therapeutic agents, making the disease as one of the most mortal in the world. There is therefore an urgent demand for better therapeutic approaches. Granulin-epithelin precursor (GEP) was identified as a potential therapeutic target from our genome-wide expression profiles study for HCC. It was an autocrine growth factor with over-expression in most HCCs, and involved in HCCs proliferation, invasion and tumorigenicity. The aim of the ...link_to_OA_fulltex