This journal issue contain abstracts of the 13th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine 2009Abstracts for Posters: no. P12BACKGROUND: Mitochondria are the principal source of reactive oxygen species (ROS) in pancreatic islets β-cells and impairment of mitochondrial functions is intrinsically related with diabetes mellitus. Hyperglycemiainduced ROS production by mitochondria is an important aspect in β-cell glucose toxicity. However, most previous studies were performed in either normal islets/single β-cells or insulinoma cells which were bathed in high glucose medium which could not mimic the pathophysiological conditions. OBJECTIVES: To compare and measure hyperglycemia-induced mitochondria ROS ge...
Diabetes is a global health problem caused primarily by the inability of pancreatic beta-cells to se...
Excessive formation of oxygen radicals is a well-established mediator of hyperglycemic damage in dia...
Abstracts for PostersThis journal issue is proceedings of ICSM 2010BACKGROUND: One of the factors re...
This journal issue is proceedings of ICSM 2010Abstracts for PostersBACKGROUND: Failure of insulin se...
Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secre...
PMID: PMC2646066 [Available on 2010/03/01]OBJECTIVE: Insulin secretion involves complex events in wh...
In this thesis, three mouse models and cell culture techniques were used to investigate genetic fact...
Diabetes mellitus is rapidly becoming the world’s most dangerous serial killer. Type 1 diabetes (T1D...
Mutations of mitochondrial DNA cause a variety of clinical syndromes. It is unclear whether impaired...
Circulating redox state changes, determined by the ratio of reduced/oxidized pairs of differ-ent met...
AIMS/HYPOTHESIS: Pancreatic beta cells chronically exposed to low glucose concentrations show signs ...
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction...
Oxidative stress and chronic inflammation are known to be associated with the development of metabo...
Objective: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depe...
Diabetes is a global health problem caused primarily by the inability of pancreatic beta-cells to se...
Excessive formation of oxygen radicals is a well-established mediator of hyperglycemic damage in dia...
Abstracts for PostersThis journal issue is proceedings of ICSM 2010BACKGROUND: One of the factors re...
This journal issue is proceedings of ICSM 2010Abstracts for PostersBACKGROUND: Failure of insulin se...
Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secre...
PMID: PMC2646066 [Available on 2010/03/01]OBJECTIVE: Insulin secretion involves complex events in wh...
In this thesis, three mouse models and cell culture techniques were used to investigate genetic fact...
Diabetes mellitus is rapidly becoming the world’s most dangerous serial killer. Type 1 diabetes (T1D...
Mutations of mitochondrial DNA cause a variety of clinical syndromes. It is unclear whether impaired...
Circulating redox state changes, determined by the ratio of reduced/oxidized pairs of differ-ent met...
AIMS/HYPOTHESIS: Pancreatic beta cells chronically exposed to low glucose concentrations show signs ...
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction...
Oxidative stress and chronic inflammation are known to be associated with the development of metabo...
Objective: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depe...
Diabetes is a global health problem caused primarily by the inability of pancreatic beta-cells to se...
Excessive formation of oxygen radicals is a well-established mediator of hyperglycemic damage in dia...
Abstracts for PostersThis journal issue is proceedings of ICSM 2010BACKGROUND: One of the factors re...