Add to ORKGResearch on neuropeptide function has advanced rapidly, yet there is still no spatio-temporally resolved method to measure the release of neuropeptides in vivo. Here we introduce Neuropeptide Release Reporters (NPRRs): novel genetically-encoded sensors with high temporal resolution and genetic specificity. Using the Drosophila larval neuromuscular junction (NMJ) as a model, we provide evidence that NPRRs recapitulate the trafficking and packaging of native neuropeptides, and report stimulation-evoked neuropeptide release events as real-time changes in fluorescence intensity, with sub-second temporal resolution
Author Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here ...
Understanding the computations that take place in brain circuits requires identifying how neurons in...
Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zo...
Research on neuropeptide function has advanced rapidly, yet there is still no spatio-temporally reso...
Neuropeptides are a class of neural signaling molecules that play a pivotal role in brain function a...
AbstractNeuropeptides are ubiquitous transmitters that have been implicated in a wide variety of phy...
The brain teems with bursts of fleeting activity. To deduce the meaning of its electrochemical flash...
Neuropeptides, which control emotion, behavior and body homeostasis, are released at nerve terminals...
Neurons convey information through trillions of connections to affect animal behavior. Communication...
Recent technical developments have transformed how neuroscientists can probe brain function. What wa...
Neuropeptides have widespread effects on behavior, but how these molecules alter the activity of the...
SummaryBackgroundNeuropeptides regulate many biological processes. Elucidation of neuropeptide funct...
Neuropeptides are a diverse group of signaling molecules used by the nervous system as mediators of ...
The brain is a structure that has fascinated generations of scientists due to its complexity and its...
Characterization of neuropeptides is still actively underway. Various resources, both animal and in...
Author Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here ...
Understanding the computations that take place in brain circuits requires identifying how neurons in...
Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zo...
Research on neuropeptide function has advanced rapidly, yet there is still no spatio-temporally reso...
Neuropeptides are a class of neural signaling molecules that play a pivotal role in brain function a...
AbstractNeuropeptides are ubiquitous transmitters that have been implicated in a wide variety of phy...
The brain teems with bursts of fleeting activity. To deduce the meaning of its electrochemical flash...
Neuropeptides, which control emotion, behavior and body homeostasis, are released at nerve terminals...
Neurons convey information through trillions of connections to affect animal behavior. Communication...
Recent technical developments have transformed how neuroscientists can probe brain function. What wa...
Neuropeptides have widespread effects on behavior, but how these molecules alter the activity of the...
SummaryBackgroundNeuropeptides regulate many biological processes. Elucidation of neuropeptide funct...
Neuropeptides are a diverse group of signaling molecules used by the nervous system as mediators of ...
The brain is a structure that has fascinated generations of scientists due to its complexity and its...
Characterization of neuropeptides is still actively underway. Various resources, both animal and in...
Author Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here ...
Understanding the computations that take place in brain circuits requires identifying how neurons in...
Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zo...