Add to ORKGSensitive and specific visualization of small biomolecules in living systems is highly challenging. We report stimulated Raman-scattering imaging of alkyne tags as a general strategy for studying a broad spectrum of small biomolecules in live cells and animals. We demonstrate this technique by tracking alkyne-bearing drugs in mouse tissues and visualizing de novo synthesis of DNA, RNA, proteins, phospholipids and triglycerides through metabolic incorporation of alkyne-tagged small precursors
Glucose is consumed as an energy source by virtually all living organisms, from bacteria to humans. ...
Sensitive and specific visualisation of biomolecules in living models is highly challenging because...
Live intracellular imaging is a valuable tool in modern diagnostics and pharmacology. Surface Enhanc...
Sensitive and specific visualization of small biomolecules in living systems is highly challenging. ...
Functional small biomolecules play indispensable roles inside cells. However, sensitive and specific...
Alkynes can be metabolically incorporated into biomolecules including nucleic acids, proteins, lipid...
Abstract: Alkynes can be metabolically incorporated into biomolecules including nucleic acids, prote...
Vibrational imaging such as Raman microscopy is a powerful technique for visualizing a variety of mo...
Innovations in light microscopy have tremendously revolutionized the way researchers study biologica...
Alkyne has a unique Raman band that does not overlap with Raman scattering from any endogenous molec...
Innovations in light microscopy have tremendously revolutionized the way researchers study biologica...
Vibrational imaging such as Raman microscopy is a powerful technique for visualizing a variety of mo...
We report a novel imaging platform, by coupling stimulated Raman scattering microscopy with small vi...
Innovations in spectroscopy principles and microscopy technol. have significantly impacted modern bi...
Live imaging of biomolecules with high specificity and sensitivity as well as minimal perturbation i...
Glucose is consumed as an energy source by virtually all living organisms, from bacteria to humans. ...
Sensitive and specific visualisation of biomolecules in living models is highly challenging because...
Live intracellular imaging is a valuable tool in modern diagnostics and pharmacology. Surface Enhanc...
Sensitive and specific visualization of small biomolecules in living systems is highly challenging. ...
Functional small biomolecules play indispensable roles inside cells. However, sensitive and specific...
Alkynes can be metabolically incorporated into biomolecules including nucleic acids, proteins, lipid...
Abstract: Alkynes can be metabolically incorporated into biomolecules including nucleic acids, prote...
Vibrational imaging such as Raman microscopy is a powerful technique for visualizing a variety of mo...
Innovations in light microscopy have tremendously revolutionized the way researchers study biologica...
Alkyne has a unique Raman band that does not overlap with Raman scattering from any endogenous molec...
Innovations in light microscopy have tremendously revolutionized the way researchers study biologica...
Vibrational imaging such as Raman microscopy is a powerful technique for visualizing a variety of mo...
We report a novel imaging platform, by coupling stimulated Raman scattering microscopy with small vi...
Innovations in spectroscopy principles and microscopy technol. have significantly impacted modern bi...
Live imaging of biomolecules with high specificity and sensitivity as well as minimal perturbation i...
Glucose is consumed as an energy source by virtually all living organisms, from bacteria to humans. ...
Sensitive and specific visualisation of biomolecules in living models is highly challenging because...
Live intracellular imaging is a valuable tool in modern diagnostics and pharmacology. Surface Enhanc...