Add to ORKGThe first enantioselective catalytic direct cross-aldol reaction that employs nonequivalent aldehydes has been accomplished using proline as the reaction catalyst. Structural variation in both the aldol donor (R_1 = Me, n-Bu, Bn, 91 to >99%) and aldol acceptor (R_2 = I-Pr, I-Bu, c-C6H11, Et, Ph, 97−99% ee) are possible while maintaining high reaction efficiency (75−88% yield). Significantly, this new aldol variant allows facile enantioselective access to a broad range of β-hydroxy aldehydes which are valuable intermediates in polyketide syntheses
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
Synthesis and successful applications in terms of chemical yields and diastereo-/enantiomeric ratios...
Synthesis and successful applications in terms of chemical yields and diastereo-/enantiomeric ratios...
The first enantioselective catalytic direct cross-aldol reaction that employs nonequivalent aldehyde...
We report here catalytic asymmetric iterative and domino cross-aldol reactions between aldehydes, en...
L-Prolinamides 2, prepared from L-proline and simple aliphatic and aromatic amines, have been found ...
https://scholarworks.moreheadstate.edu/student_scholarship_posters/1088/thumbnail.jp
L-Prolinamides 2, prepared from L-proline and simple aliphatic and aromatic amines, have been found ...
The use of simple (S)-proline as catalyst for the intermolecular direct aldol reaction at the beginn...
The synthesis of multifunctional organic catalysts, easily obtained by the condensation of (S)-proli...
Copyright © 2013 Heli Kylmälä, et al. This is an open access article distributed under the Creative ...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
Modification of the pyrrolidinyl backbone of proline has not been quite successful for improving the...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
Synthesis and successful applications in terms of chemical yields and diastereo-/enantiomeric ratios...
Synthesis and successful applications in terms of chemical yields and diastereo-/enantiomeric ratios...
The first enantioselective catalytic direct cross-aldol reaction that employs nonequivalent aldehyde...
We report here catalytic asymmetric iterative and domino cross-aldol reactions between aldehydes, en...
L-Prolinamides 2, prepared from L-proline and simple aliphatic and aromatic amines, have been found ...
https://scholarworks.moreheadstate.edu/student_scholarship_posters/1088/thumbnail.jp
L-Prolinamides 2, prepared from L-proline and simple aliphatic and aromatic amines, have been found ...
The use of simple (S)-proline as catalyst for the intermolecular direct aldol reaction at the beginn...
The synthesis of multifunctional organic catalysts, easily obtained by the condensation of (S)-proli...
Copyright © 2013 Heli Kylmälä, et al. This is an open access article distributed under the Creative ...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
Modification of the pyrrolidinyl backbone of proline has not been quite successful for improving the...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol rea...
Synthesis and successful applications in terms of chemical yields and diastereo-/enantiomeric ratios...
Synthesis and successful applications in terms of chemical yields and diastereo-/enantiomeric ratios...