The two peptides distamycin A(D) and 1-methylimidazole-2-carboxamide-netropsin (2-ImN) simultaneously bind the five-base-pair sequence 5'-TGTTA-3'. Footprinting experiments indicate that both molecules are necessary for binding to this sequence while affinity cleaving data define the orientations with which each peptide binds to this sequence. The footprinting and affinity cleaving data are consistent with a model wherein the two peptides bind as a side-by-side antiparallel heterodimer in the minor groove of double-helical DNA
A four-ring tripeptide containing alternating imidazole and pyrrole carboxamides specifically binds ...
Affinity cleaving proteins have been synthesized based on the DNA-binding domain of the yeast trans...
Using two direct methods we have studied the binding locations and site sizes of distamycin and pent...
The two peptides distamycin A(D) and 1-methylimidazole-2-carboxamide-netropsin (2-ImN) simultaneousl...
The designed peptides pyridine-2-carboxamide-netropsin (2-PyN) and 1-methylimidazole-2-carboxamide-n...
The designed peptides pyridine-2-carboxamidonetropsin (2-PyN) and 1-methylimidazole-2-carboxamidonet...
NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in ...
The designed peptide 1-methylimidazole-2-carboxamide netropsin (2-ImN) binds specifically to the seq...
The tripeptide ImPImP containing alternating imidazole and pyrrole carboxamides specifically binds t...
While 1:1 peptide-DNA models aided in the design of oligopeptides for recognition of long tracts of...
The cationic peptide ligands distamycin and netropsin bind noncovalently to the minor groove of DNA....
The design of sequence-specific cleaving molecules for double-helical DNA requires the attachment of...
Sequence-specific bidentate binding to double-stranded (ds)-DNA by 'tail-to-tail' linked dimeric, di...
One approach to the design of sequence specific DNA binding molecules that read large sequences of r...
Polyamides composed of pyrrole (Py) and imidazole (Im) amino acids bind as antiparallel, side-by sid...
A four-ring tripeptide containing alternating imidazole and pyrrole carboxamides specifically binds ...
Affinity cleaving proteins have been synthesized based on the DNA-binding domain of the yeast trans...
Using two direct methods we have studied the binding locations and site sizes of distamycin and pent...
The two peptides distamycin A(D) and 1-methylimidazole-2-carboxamide-netropsin (2-ImN) simultaneousl...
The designed peptides pyridine-2-carboxamide-netropsin (2-PyN) and 1-methylimidazole-2-carboxamide-n...
The designed peptides pyridine-2-carboxamidonetropsin (2-PyN) and 1-methylimidazole-2-carboxamidonet...
NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in ...
The designed peptide 1-methylimidazole-2-carboxamide netropsin (2-ImN) binds specifically to the seq...
The tripeptide ImPImP containing alternating imidazole and pyrrole carboxamides specifically binds t...
While 1:1 peptide-DNA models aided in the design of oligopeptides for recognition of long tracts of...
The cationic peptide ligands distamycin and netropsin bind noncovalently to the minor groove of DNA....
The design of sequence-specific cleaving molecules for double-helical DNA requires the attachment of...
Sequence-specific bidentate binding to double-stranded (ds)-DNA by 'tail-to-tail' linked dimeric, di...
One approach to the design of sequence specific DNA binding molecules that read large sequences of r...
Polyamides composed of pyrrole (Py) and imidazole (Im) amino acids bind as antiparallel, side-by sid...
A four-ring tripeptide containing alternating imidazole and pyrrole carboxamides specifically binds ...
Affinity cleaving proteins have been synthesized based on the DNA-binding domain of the yeast trans...
Using two direct methods we have studied the binding locations and site sizes of distamycin and pent...
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