Everything expands and changes and so does our knowledge of biology. Everybody says that this is so. Even though I have been a biologist only 30 years, still I have myself seen sufficient change in our science to be assured that such change is in fact taking place. In the first place we have learned a lot of plain old facts: How respiration works, a lot about how photosynthesis works (but not all), a lot about how all the different amino acids get made, a lot about what hormones there are, a little about how hormones work, a lot about the description of how development takes place, a great deal about genetic material. We have seen enough to convince me that there is one great class of biological problems which, if followed to ...