An asymmetric palladium-catalyzed conjugate addition reaction of arylboronic acids to enone substrates was investigated mechanistically. Desorption electrospray ionization coupled to mass spectrometry was used to identify intermediates of the catalytic cycle and delineate differences in substrate reactivity. Our findings provide evidence for the catalytic cycle proceeding through formation of an arylpalladium(II) cation, subsequent formation of an arylpalladium–enone complex, and, ultimately, formation of the new C–C bond. Reaction monitoring in both positive and negative ion modes revealed that 4-iodophenylboronic acid formed a relatively stable trimeric species under the reaction conditions
The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboron...
The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboron...
Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing...
An asymmetric palladium-catalyzed conjugate addition reaction of arylboronic acids to enone substrat...
This account describes our laboratory’s efforts in the development of a palladium-catalyzed asymmetr...
This account describes our laboratory’s efforts in the development of a palladium-catalyzed asymmetr...
Enantioselective conjugate additions of arylboronic acids to β-substituted cyclic enones have been p...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
Enantioselective conjugate additions of arylboronic acids to β-substituted cyclic enones have been p...
Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing...
Enantioselective conjugate additions of arylboronic acids to β-substituted cyclic enones have been p...
The first enantioselective Pd-catalyzed construction of all-carbon quaternary stereocenters via 1,4-...
The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboron...
The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboron...
Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing...
An asymmetric palladium-catalyzed conjugate addition reaction of arylboronic acids to enone substrat...
This account describes our laboratory’s efforts in the development of a palladium-catalyzed asymmetr...
This account describes our laboratory’s efforts in the development of a palladium-catalyzed asymmetr...
Enantioselective conjugate additions of arylboronic acids to β-substituted cyclic enones have been p...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsat...
Enantioselective conjugate additions of arylboronic acids to β-substituted cyclic enones have been p...
Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing...
Enantioselective conjugate additions of arylboronic acids to β-substituted cyclic enones have been p...
The first enantioselective Pd-catalyzed construction of all-carbon quaternary stereocenters via 1,4-...
The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboron...
The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboron...
Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing...