The aim of the study was to investigate the anticancer effects and the molecular mechanisms of deguelin on Jurkat cells. Cell viability was assessed by MTT assay. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assay and transmission electron microscopy were used to detect cell apoptosis. A propidium iodide method was used to study cell cycle distribution. RT-PCR and Western blotting were employed to assess the expression levels of steroid receptor coactivator-3 (SRC-3), nuclear factor-κB (NF-κB) and some apoptosis related genes, including Bcl-2 and Bcl-xL. Deguelin was able to inhibit cell proliferation by a cell-cycle arrest in the G1/G 0 phase and induce apoptosis in Jurkat cells in vitro, with a 24-h IC50 va...
(Leguminossae) has shown both antiproliferative actions in various cancers including breast as well...
Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung m...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annua...
Objective: To investigate the effects of deguelin on the proliferation inhibition and apoptosis indu...
To investigate the anti-cancer effects and molecular mechanism of deguelin on the human leukemia HL-...
<p>Hep-2 cells were exposed to deguelin at a various concentration (10, 25, 50, 100 and 200 µM) for ...
The study was purposed to investigate the effect of deguelin on expression of nucleoporin 98 (nup98)...
OBJECTIVE: To investigate antitumor activity and molecular mechanism of deguelin to the human U937 l...
Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor ...
[[abstract]]It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family...
B-cell chronic lymphocytic leukemia (CLL) remains an incurable disease, and despite the improvement ...
This is an open access article distributed under the terms of the Creative Commons Attribution Licen...
Breast cancer is the most common cancer and the leading cause of cancer related deaths amongst women...
This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5 % of all cancers diagnosed annu...
(Leguminossae) has shown both antiproliferative actions in various cancers including breast as well...
Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung m...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annua...
Objective: To investigate the effects of deguelin on the proliferation inhibition and apoptosis indu...
To investigate the anti-cancer effects and molecular mechanism of deguelin on the human leukemia HL-...
<p>Hep-2 cells were exposed to deguelin at a various concentration (10, 25, 50, 100 and 200 µM) for ...
The study was purposed to investigate the effect of deguelin on expression of nucleoporin 98 (nup98)...
OBJECTIVE: To investigate antitumor activity and molecular mechanism of deguelin to the human U937 l...
Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor ...
[[abstract]]It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family...
B-cell chronic lymphocytic leukemia (CLL) remains an incurable disease, and despite the improvement ...
This is an open access article distributed under the terms of the Creative Commons Attribution Licen...
Breast cancer is the most common cancer and the leading cause of cancer related deaths amongst women...
This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5 % of all cancers diagnosed annu...
(Leguminossae) has shown both antiproliferative actions in various cancers including breast as well...
Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung m...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annua...