Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004

Background: Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004. Methods: The analysis included 5995 men and non-pregnant women aged ≥ 40 years with no missing data in variables of interest. PAD was defined as ankle-brachial blood pressure index (ABI) 90 ml/min/1.73 m2), the odds ratio increased to 4.22 (95% CI 1.45-12.35) (p = 0.010). Conclusion: Elevated serum ALP is correlated with PAD, independent of other traditional cardiovascular risk factors. © 2008 Elsevier Ireland Ltd. All rights reserved.link_to_subscribed_fulltex