Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications
- Wong, D
- Mackiewicz, J
- Lommatzsch, A
- Kirchhof, B
- Hilgers, RD
- Li, X
- Kirchhof, B
- Ocklenburg, C
- Schrage, N
- Höhne, K
- Ottenberg, D
- Kirchhof, B
- Joussen, AM
- Holz, FG
- Rindsfüser, M
- Lipski, A
- Hebbar, G
- Joussen, AM
- Hilgers, RD
- Ocklenburg, C
- Schwartz, S
- Garnett, L
- Hoerauf, H
- Heimann, H
- Groenewald, C
- BartzSchmidt, U
- Varapi, G
- Grisanti, S
- Foerster, MH
- Domeier, E
- Herrmann, M
- Wrede, J
- Krömer, I
- Lemmen, KD
- Jungfermann, P
- Hilgers, RD
- Eter, N
- Handzel, D
- Engelmann, K
- Dithmar, S
- Klatt, C
- Prinz, B
- Dahlke, C
- Bechrakis, N
- Binder, S
- Bornfeld, N
- Bunse, A
- Eriksson, L
- Belting, C
- Kirchhof, B
- Yörük, E
- Llacer, H
- Jöres, S
- Kusserow, C
- Crafoord, S
- Carlsson, JO
- Peperkamp, E
- Pearce, I
- Rizzo, S
- van Overdam, K
- Müller, M
- Shanks, G
- Stolba, U
- Meireles, A
- Schrage, N
- Salacz, G
- Roider, J
- Szurman, P
- Veckeneer, M
- Walter, P
- Ocklenburg, C
- Hilgers, RD
- Wiechens, B
- Joussen, AM
DOIAbstract
Purpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and p...
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