Apoptosis in mouse peritoneal macrophages induced by oxidised low-density lipoprotein and prevention by the polysaccharide kreskin

Exposure of mouse peritoneal macrophages (MPM) to oxidised low-density lipoprotein (Ox-LDL) induced apoptosis, characterised by DNA fragmentation with a classical ladder pattern and chromatin condensation. Exposure of MPM to native LDL and acetylated LDL did not do so. DNA fragmentation caused by Ox-LDL was dependent on concentration and time. The polysaccharide kreskin, injected peritoneally into mice, protected their macrophages from apoptosis caused by Ox-LDL.link_to_subscribed_fulltex