Add to ORKGThe nucleotide sequences of 27 T-cell receptor β cDNA clones isolated from a human peripheral lymphocyte library were determined and compared to five additional published sequences. These cDNA clones represent 22 distinct T-cell receptor β-chain variable region (Vβ) gene segment sequences, which fall into 15 different Vβ gene subfamilies, each containing six or fewer members. From this analysis, we estimate that the repertoire of expressed human Vβ genes is <59, apparently much smaller than the immunoglobulin heavy chain and light chain variable region (VH and VL) repertoires. Variability plots comparing these human Vβ regions with each other and with published mouse Vβ regions provide evidence for only four hypervariable regions homologous...
T-cell specificity is determined by the T-cell receptor, a heterodimeric protein coded for by an ext...
Murine T cells express either of 2 antigen receptors on their surface: αβ or γδ T cell receptors. ...
Serological and molecular genetic analyses of T-cell clones have shown that the T-cell antigen recep...
AbstractThe availability of the complete genomic sequences of the human and mouse T cell receptor lo...
The T-cell receptor (TCR) plays a central role in the immune system, and >90% of human T cells prese...
In our studies we have focused on the issue of variability and diversity of the $\gamma$ (or $\delta...
Four distinct T-cell antigen-receptor gene loci have now been identified and partly characterized: ɑ...
A diverse T cell receptor (TCR) repertoire is essential for adaptive immune responses and is generat...
We examine the rules governing Ti beta variable (V) gene segment usage in the formation of T cell an...
Conclusions: In conclusion, the large number of studies on human γδ T cells have shown that these ly...
For thymic selection and responses to pathogens, T cells interact through their {alpha}{beta} T cell...
We have combined three different methods, deletion mapping of T-cell lines, field-inversion gel elec...
The human T-cell repertoire is complex and is generated by the rearrangement of variable (V), divers...
The T cell receptor (TCR) repertoire is diverse, thus allowing recognition of a wide range of pathog...
The T cell receptor (TCR) repertoire is diverse, thus allowing recognition of a wide range of pathog...
T-cell specificity is determined by the T-cell receptor, a heterodimeric protein coded for by an ext...
Murine T cells express either of 2 antigen receptors on their surface: αβ or γδ T cell receptors. ...
Serological and molecular genetic analyses of T-cell clones have shown that the T-cell antigen recep...
AbstractThe availability of the complete genomic sequences of the human and mouse T cell receptor lo...
The T-cell receptor (TCR) plays a central role in the immune system, and >90% of human T cells prese...
In our studies we have focused on the issue of variability and diversity of the $\gamma$ (or $\delta...
Four distinct T-cell antigen-receptor gene loci have now been identified and partly characterized: ɑ...
A diverse T cell receptor (TCR) repertoire is essential for adaptive immune responses and is generat...
We examine the rules governing Ti beta variable (V) gene segment usage in the formation of T cell an...
Conclusions: In conclusion, the large number of studies on human γδ T cells have shown that these ly...
For thymic selection and responses to pathogens, T cells interact through their {alpha}{beta} T cell...
We have combined three different methods, deletion mapping of T-cell lines, field-inversion gel elec...
The human T-cell repertoire is complex and is generated by the rearrangement of variable (V), divers...
The T cell receptor (TCR) repertoire is diverse, thus allowing recognition of a wide range of pathog...
The T cell receptor (TCR) repertoire is diverse, thus allowing recognition of a wide range of pathog...
T-cell specificity is determined by the T-cell receptor, a heterodimeric protein coded for by an ext...
Murine T cells express either of 2 antigen receptors on their surface: αβ or γδ T cell receptors. ...
Serological and molecular genetic analyses of T-cell clones have shown that the T-cell antigen recep...