Despite the use of statin therapy, a significant proportion of patients with coronary artery disease (CAD) still develop cardiovascular events. We hypothesized that development of mitochondrial dysfunction (MD) after statin therapy might be linked to endothelial dysfunction and thus limiting its beneficial effects. We studied the effect of MD on endothelial function in 119 patients with CAD on long-term statins (> 1 year). Brachial artery flow-mediated dilation (FMD) was assessed by high-resolution ultrasonography and blood levels of lactate, pyruvate, fasting glucose, and lipids were measured. MD (defined by a lactate/pyruvate ratio >75th percentile of the age- and sex-matched normal controls, i.e., ≥18) was observed in 43/119(36%) patient...
Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radi...
Background/Objectives: Statins are widely used to treat hyperlipidemia and lower cardiovascular dis...
<p>Mitochondria are not only the major producers of adenosine triphosphate, but also an endogenous s...
Mitochondrial diseases (MDs) are a clinically heterogeneous group of disorders characterized by impa...
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes. Improv...
Statins induce acute vasorelaxation which may contribute to the overall benefits of statins in the t...
Cardiovascular disease (CVD) accounts for >17 million deaths globally every year, and this figure...
In the United States there are more than 40 million Americans that treat or prevent hyperlipidemia a...
Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most...
Background: Cardiovascular diseases (CVDs) are a leading risk factor for mortality worldwide and the...
Abstract Background Statins improve the endothelial function in patients with coronary artery diseas...
Despite the use of current therapies for lipid modification, glucose regulation, and blood pressure ...
Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EA...
Statins are cholesterol-lowering medicines utilized worldwide and are associated with reduced risk o...
Background-: Treatment with statins improves clinical outcome, but the exact mechanisms of pleiotrop...
Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radi...
Background/Objectives: Statins are widely used to treat hyperlipidemia and lower cardiovascular dis...
<p>Mitochondria are not only the major producers of adenosine triphosphate, but also an endogenous s...
Mitochondrial diseases (MDs) are a clinically heterogeneous group of disorders characterized by impa...
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes. Improv...
Statins induce acute vasorelaxation which may contribute to the overall benefits of statins in the t...
Cardiovascular disease (CVD) accounts for >17 million deaths globally every year, and this figure...
In the United States there are more than 40 million Americans that treat or prevent hyperlipidemia a...
Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most...
Background: Cardiovascular diseases (CVDs) are a leading risk factor for mortality worldwide and the...
Abstract Background Statins improve the endothelial function in patients with coronary artery diseas...
Despite the use of current therapies for lipid modification, glucose regulation, and blood pressure ...
Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EA...
Statins are cholesterol-lowering medicines utilized worldwide and are associated with reduced risk o...
Background-: Treatment with statins improves clinical outcome, but the exact mechanisms of pleiotrop...
Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radi...
Background/Objectives: Statins are widely used to treat hyperlipidemia and lower cardiovascular dis...
<p>Mitochondria are not only the major producers of adenosine triphosphate, but also an endogenous s...