High-level expression of Rad51, a key factor in homologous recombination, has been observed in a variety of human malignancies. This study was aimed to evaluate Rad51 expression to serve as prognostic marker in non-small-cell lung cancer (NSCLC). A total of 383 non-small-cell lung tumours were analysed immunohistochemically on NSCLC tissue microarrays. High-level Rad51 expression was observed in 29.4% (100 out of 340) of cases. Patients whose tumours displayed high-level Rad51 expression showed a significantly shorter median survival time of 19 vs 68 months (P < 0.0001, log-rank test). Similarly T status, N status, M status, clinical stage and histological tumour grade were significant prognostic markers in univariate Cox survival analysis....
Background. Neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) is b...
The RAD51 recombinase is a critical effector of Homologous Recombination (HR), which is an essential...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
OBJECTIVES: In response to DNA damage, recombination proteins are relocalized into sub-nuclear compl...
Rad51, a DNA-repair-related gene, has been reported to be involved in multiple cancers. However, its...
Objective RAD54 homolog B (RAD54B), a member of the SNF2/SWI2 superfamily, is implicated in homologo...
Targeting deficient mechanisms of cellular DNA repair still represents the basis for the treatment o...
Purpose. To examine the expression of RAD51 in oral squamous cell carcinoma (OSCC) and analyze its c...
Although RAD51 associated protein 1 (RAD51AP1) is crucial in genome stability maintenance, it also p...
Although RAD51 associated protein 1 (RAD51AP1) is crucial in genome stability maintenance, it also p...
OBJECTIVES DNA repair proteins have emerged as potential predictors for immunotherapy response al...
Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role ...
BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However...
Impaired DNA damage response (DDR) may play a fundamental role in the pathogenesis of breast cancer ...
Rad51 is the key enzyme for homologous recombination, an evolutionarily conserved mechanism for the ...
Background. Neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) is b...
The RAD51 recombinase is a critical effector of Homologous Recombination (HR), which is an essential...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
OBJECTIVES: In response to DNA damage, recombination proteins are relocalized into sub-nuclear compl...
Rad51, a DNA-repair-related gene, has been reported to be involved in multiple cancers. However, its...
Objective RAD54 homolog B (RAD54B), a member of the SNF2/SWI2 superfamily, is implicated in homologo...
Targeting deficient mechanisms of cellular DNA repair still represents the basis for the treatment o...
Purpose. To examine the expression of RAD51 in oral squamous cell carcinoma (OSCC) and analyze its c...
Although RAD51 associated protein 1 (RAD51AP1) is crucial in genome stability maintenance, it also p...
Although RAD51 associated protein 1 (RAD51AP1) is crucial in genome stability maintenance, it also p...
OBJECTIVES DNA repair proteins have emerged as potential predictors for immunotherapy response al...
Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role ...
BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However...
Impaired DNA damage response (DDR) may play a fundamental role in the pathogenesis of breast cancer ...
Rad51 is the key enzyme for homologous recombination, an evolutionarily conserved mechanism for the ...
Background. Neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) is b...
The RAD51 recombinase is a critical effector of Homologous Recombination (HR), which is an essential...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...