Accumulation of beta-amyloid (Aβ) peptides in senile plaques is one of the pathological hallmarks in Alzheimer's disease (AD), which can trigger apoptosis. We have previously demonstrated that Aβ triggered calcium release from the ER. Depletion of ER Ca2+ ions has been reported leading to unfolded protein responses (UPR). While hypothesis has been made about UPR and neurodegeneration in AD, little is known about the effects of extracellular accumulation of Aβ on UPR. We have shown previously that activation of PKR in Aβ-triggered apoptosis. Since UPR can trigger PKR, our study aims to elucidate whether extracellular accumulation of Aβ peptides induce UPR in cultured neurons. Our results showed that Aβ could not trigger UPR signalings includ...
Dysregulation of Ca(2+) homeostasis is considered to contribute to the toxic action of the Alzheimer...
Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response ...
Alzheimer’s disease (AD) is a progressive and irreversible brain disorder which results in memory lo...
Accumulation of beta-amyloid (Aβ) peptides in senile plaques is one of the pathological hallmarks in...
Extracellular accumulation of beta-amyloid (A ) peptides in senile plaques is one of the patholog...
Accumulation of β-amyloid (Aβ) peptide has long been considered as one of the toxic factors contribu...
Beta-amyloid (Aβ) peptide has been suggested to play important roles in the pathogenesis of Alzheime...
One of the hallmarks of Alzheimer's disease is extracellular accumulation of senile plaques composed...
Recent findings suggest that apoptosis could be implicated in the neuronal death in Alzheimer's dise...
Beta-amyloid (Aβ) peptide has been proposed to play important roles in the pathogenesis of Alzheimer...
AbstractAbnormal accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of A...
AbstractHere we investigated the role of the amyloid precursor protein (APP) in regulation of Ca2+ s...
In this study, we analyzed whether ER Ca2+ release, induced by amyloid-[beta] (A[beta]) and prion (P...
One of the pathological hallmarks of Alzheimer’s disease (AD) is the accumulation of beta-amyloid (...
Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Abeta), whic...
Dysregulation of Ca(2+) homeostasis is considered to contribute to the toxic action of the Alzheimer...
Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response ...
Alzheimer’s disease (AD) is a progressive and irreversible brain disorder which results in memory lo...
Accumulation of beta-amyloid (Aβ) peptides in senile plaques is one of the pathological hallmarks in...
Extracellular accumulation of beta-amyloid (A ) peptides in senile plaques is one of the patholog...
Accumulation of β-amyloid (Aβ) peptide has long been considered as one of the toxic factors contribu...
Beta-amyloid (Aβ) peptide has been suggested to play important roles in the pathogenesis of Alzheime...
One of the hallmarks of Alzheimer's disease is extracellular accumulation of senile plaques composed...
Recent findings suggest that apoptosis could be implicated in the neuronal death in Alzheimer's dise...
Beta-amyloid (Aβ) peptide has been proposed to play important roles in the pathogenesis of Alzheimer...
AbstractAbnormal accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of A...
AbstractHere we investigated the role of the amyloid precursor protein (APP) in regulation of Ca2+ s...
In this study, we analyzed whether ER Ca2+ release, induced by amyloid-[beta] (A[beta]) and prion (P...
One of the pathological hallmarks of Alzheimer’s disease (AD) is the accumulation of beta-amyloid (...
Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Abeta), whic...
Dysregulation of Ca(2+) homeostasis is considered to contribute to the toxic action of the Alzheimer...
Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response ...
Alzheimer’s disease (AD) is a progressive and irreversible brain disorder which results in memory lo...