Methods For Enhancing The Production Of Interferon In Cell Culture

Methods For Enhancing The Production Of Interferon In Animal Cell Culture Are Described. These Methods Rely On The Manipulation Of The Cellular Levels Of Certain Inducers Of Interferon Production, In Particular Cellular Levels Of Double-Stranded-Rna-Dependent Kinase (Dsrna-Pkr, Or Pkr). In Cell Cultures That Overproduce Pkr, Interferon Synthesis Is Induced To High Levels, And Significant Amounts Of Interferon Can Be Recovered Without Conventional Induction Of Interferon By Virus.published_or_final_versio